Volume 94 Issue 49 | p. 10 | News of The Week
Issue Date: December 19, 2016

A two-punch attack from CRISPR knocks out HIV in cells

The gene-editing technology mutates the virus’s DNA, blocking its replication in immune cells
Department: Science & Technology
News Channels: Biological SCENE
Keywords: infectious disease, biotechnology, CRISPR, HIV, AIDS, CRISPR/Cas9, T cell

When HIV infects a person, the virus integrates its DNA into the genomes of the person’s immune system cells. Daily doses of antiretroviral drugs suppress replication of that viral DNA, but it’s not a cure.

“An ideal situation would be a single treatment, rather than lifelong therapy,” says Atze T. Das of the University of Amsterdam. In a new study, Das and colleagues report progress on a possible one-time therapy. They permanently inactivated HIV in . . .

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