Volume 94 Issue 5 | p. 29 | Concentrates
Issue Date: February 1, 2016

Iron Catalysts For Enantioselective Hydrogenations

Catalysis: Abundant metal catalyst transforms ketones and imines into chiral alcohols and amines
Department: Science & Technology
News Channels: Organic SCENE
Keywords: hydrogenation, enantioselective, iron

Making chiral alcohols and amines via enantioselective hydrogenation of ketones and imines is a cinch for chemists. But the ruthenium, iridium, and rhodium catalysts usually used for such transformations are expensive and toxic, which makes them unattractive for industrial applications. Because many pharmaceuticals, agrochemicals, flavors, and fragrances feature alcohols or amines with a stereogenic carbon at the α-position, chemists have been developing inexpensive, nontoxic iron catalysts capable of doing the same reaction. Until now, however, . . .

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