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Web Date: January 4, 2016

Chemists Merge Two Fundamental Reactions To Achieve A New Cross-Coupling Scheme

Organic Chemistry: Combining a Suzuki-Miyaura catalytic cycle with a stoichiometric metallate rearrangement yields a novel synthetic platform
Department: Science & Technology
News Channels: Organic SCENE
Keywords: cross-coupling, transmetallation, boronate

In a case of teaching an old dog a new trick, Boston College researchers have discovered how to merge two important chemical transformations involving widely used organoboron reagents into one. Liang Zhang, James P. Morken, and coworkers found they could combine key steps of the Suzuki-Miyaura cross-coupling catalytic cycle with a stoichiometric metallate rearrangement process to generate a multicomponent catalytic reaction that delivers chiral products. This new concept, which they call . . .

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ISSN 0009-2347
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