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Web Date: January 7, 2016

Researchers Make Amines With Remote Chiral Centers In One Step

Organic Synthesis: Technique provides first direct single-step route to amines with chiral centers three or more carbon atoms from the amine nitrogen
Department: Science & Technology
News Channels: Organic SCENE
Keywords: synthesis, amines, γ-chiral amine, δ-chiral amine, reductive relay hydroamination

Organic molecules that have a chiral center three or four carbon atoms from an amine nitrogen atom—called γ- and δ-chiral amines, respectively—are important structural elements in many pharmaceutical agents and natural products. So it would be nice if they were easy to make synthetically. But up to now, synthetic chemists have not been able to controllably add amines and other functional groups to positions more than one or two carbons from chiral centers without resorting . . .

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Chemical & Engineering News
ISSN 0009-2347
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