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Web Date: February 23, 2016

Nanoparticle antioxidants offer potential Alzheimer’s therapy

Nanomedicines: Coated ceria nanoparticles target mitochondrial malfunction to reduce neuron death in mice
Department: Science & Technology
News Channels: Biological SCENE, Nano SCENE
Keywords: Alzheimer’s disease, nanoparticle therapy, mitochondria, neuron death, ceria nanoparticles, oxidative species

Mitochondria, a cell’s power plants, have been implicated in several neurodegenerative diseases. In Alzheimer’s disease, dysfunctioning mitochondria produce abnormally high levels of reactive oxidative species that trigger brain cell death. Researchers have now made cerium oxide nanoparticles that selectively gather inside mitochondria and act as antioxidants to suppress neuron death in mice (ACS Nano 2016, DOI: 10.1021/acsnano.5b08045). Researchers hope this approach could ultimately be used to . . .

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Chemical & Engineering News
ISSN 0009-2347
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