Web Date: July 25, 2016
Shortcut leads to branched tryptophans
Dressing up common amino acids by adding chemical groups creates unusual amino acids that can have novel catalytic, medicinal, and other properties. But adding a methyl group to the amino acid tryptophan’s β carbon is so thorny that it’s rarely done. Now, bioengineers have used directed evolution to produce an enzyme that catalyzes the synthesis of β-methyltryptophan analogs in just one step (J. Am. Chem. Soc. 2016, DOI: . . .
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