Volume 95 Issue 12 | pp. 27-28
Issue Date: March 20, 2017

DNA may act as a wire during replication

Replication proteins may use DNA charge transport to communicate with one another via their iron-sulfur clusters
Department: Science & Technology
Keywords: biochemistry, biological chemistry, nucleic acids

DNA replication is a complicated affair: Proteins must identify where on DNA to start replicating, unwind the double helix, synthesize a primer, and then elongate the DNA strand from the end of that primer. The activity of these proteins is carefully orchestrated to ensure the DNA gets replicated accurately.

Increasingly, biochemical researchers are finding that many of the proteins involved in DNA replication incorporate iron-sulfur clusters, which enzymes commonly use for electron transfer. Experiments now . . .

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