Issue Date: March 20, 2017
Reversing resistance to a tuberculosis antibiotic
Some of the most powerful tuberculosis antibiotics are prodrugs, compounds that need to be chemically modified by the disease-causing pathogen itself to become deadly. For those who study antibiotic resistance, it’s no surprise that Mycobacterium tuberculosis has evolved ways to avoid converting these prodrugs into lethal armaments. The bacterium’s resistance strategies “seriously undermine efforts to control the global epidemic of tuberculosis” and are partly responsible for the 250,000 drug-resistant, tuberculosis-caused deaths in 2015, note a . . .
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- Chemical & Engineering News
- ISSN 0009-2347
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