Volume 95 Issue 12 | p. 5 | News of The Week
Issue Date: March 20, 2017

Reversing resistance to a tuberculosis antibiotic

Small molecule breathes new life into the tuberculosis drug ethionamide
Department: Government & Policy
News Channels: Biological SCENE
Keywords: antibiotics, tuberculosis, resistance, prodrug

Some of the most powerful tuberculosis antibiotics are prodrugs, compounds that need to be chemically modified by the disease-causing pathogen itself to become deadly. For those who study antibiotic resistance, it’s no surprise that Mycobacterium tuberculosis has evolved ways to avoid converting these prodrugs into lethal armaments. The bacterium’s resistance strategies “seriously undermine efforts to control the global epidemic of tuberculosis” and are partly responsible for the 250,000 drug-resistant, tuberculosis-caused deaths in 2015, note a . . .

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