Volume 95 Issue 2 | p. 8 | Concentrates
Issue Date: January 9, 2017

New strategy to prevent blood clots could come with lower bleeding risk

Previously understudied drug target could offer safer, more effective treatments for some cardiovascular diseases
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: drug development, blood clotting, thrombin, PAR1, PAR4

People with a high risk of suffering from a heart attack or stroke often take drugs that prevent formation of clots in their blood vessels. These drugs have a narrow so-called therapeutic window: Dosages that are high enough to effectively limit harmful clotting can also increase a person’s risk of life-threatening bleeding. A team of researchers at Bristol-Meyers Squibb and the University of Montreal reports a new strategy that could widen that window (Sci. Transl. . . .

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