Issue Date: May 15, 2017
Making antibodies minus the cells
Monoclonal antibodies (mAbs)—proteins engineered to bind to particular antigens—can serve as medications for cancer, autoimmune diseases, and other conditions. During mAb development, researchers often tweak the antibody’s underlying DNA sequence and screen for variants that give the highest yields when expressed in cells. Chinese hamster ovary (CHO) cells are typically used to produce these variants for screening, but that process takes a minimum of seven days to express the proteins. Researchers have now taken cells . . .
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