Volume 95 Issue 20 | p. 13 | Concentrates
Issue Date: May 15, 2017

Making antibodies minus the cells

A cell-free synthesis method could speed up monoclonal antibody screening
Department: Science & Technology
News Channels: Biological SCENE
Keywords: biologics, monoclonal antibody, cell-free synthesis, Chinese hamster ovary, protein drugs

Monoclonal antibodies (mAbs)—proteins engineered to bind to particular antigens—can serve as medications for cancer, autoimmune diseases, and other conditions. During mAb development, researchers often tweak the antibody’s underlying DNA sequence and screen for variants that give the highest yields when expressed in cells. Chinese hamster ovary (CHO) cells are typically used to produce these variants for screening, but that process takes a minimum of seven days to express the proteins. Researchers have now taken cells . . .

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