Volume 95 Issue 29 | p. 5 | News of The Week
Issue Date: July 17, 2017 | Web Date: July 14, 2017

Treatment-resistant cancers have Achilles’ heel

Common vulnerability is druggable pathway leading to iron-induced cell death
Department: Science & Technology
Keywords: cancer, peroxidase, chemical biology, screening

Through mutations or changes in gene expression patterns, some cancer cells become resistant to common treatments such as radiation, chemotherapy, targeted drug therapy, and immunotherapy.

A new study reports that these resistant cancers do have a vulnerability: They depend on an enzyme to protect them from iron-produced free radicals (Nature 2017, DOI: 10.1038/nature23007). The work opens a potential new route to . . .

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