Issue Date: September 11, 2017 | Web Date: September 6, 2017
Synthetic simplification of hallucinogen pays off
Salvinorin A, a hallucinogen produced by the Mexican plant Salvia divinorum, holds promise for treating itch and pain because it activates the kappa opioid receptor while avoiding the mu opioid receptor, a sister receptor that’s been associated with opioid abuse. Chemists have tried to synthesize salvinorin A so that they could alter the structure to sidestep the compound’s psychoactive effects while preserving its analgesic properties. But salvinorin A’s scaffold has been challenging to recreate.
Now, . . .
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- Chemical & Engineering News
- ISSN 0009-2347
- Copyright © American Chemical Society