Volume 95 Issue 36 | p. 6 | News of The Week
Issue Date: September 11, 2017 | Web Date: September 6, 2017

Synthetic simplification of hallucinogen pays off

ChemRxiv paper discloses total synthesis of salvinorin A analog that suppresses itch in mice
Department: Science & Technology
Keywords: Synthesis, kappa opioid receptor, strategic bond analysis, total synthesis, ryan shenvi

Salvinorin A, a hallucinogen produced by the Mexican plant Salvia divinorum, holds promise for treating itch and pain because it activates the kappa opioid receptor while avoiding the mu opioid receptor, a sister receptor that’s been associated with opioid abuse. Chemists have tried to synthesize salvinorin A so that they could alter the structure to sidestep the compound’s psychoactive effects while preserving its analgesic properties. But salvinorin A’s scaffold has been challenging to recreate.

Now, . . .

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