Issue Date: January 23, 2017 | Web Date: January 19, 2017
Making aptamers with biology’s help
Scientists simulate evolution in the lab by introducing mutations iteratively into biomolecules such as nucleic acids and selecting for desired properties. When carrying this process out specifically on RNA molecules, they can evolve the RNAs to bind specific small molecules. But many of these so-called aptamers don’t bind well to their targets when put inside cells because they don’t fold into stable structures.
“As we solved the structures of naturally occurring aptamers, we noticed they . . .
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- Chemical & Engineering News
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