Volume 95 Issue 8 | p. 8 | News of The Week
Issue Date: February 20, 2017 | Web Date: February 15, 2017

Pinning a bull’s-eye on cancer cells

Bioorthogonal technique adds azide groups to cancer cell surfaces for selective drug targeting
Department: Science & Technology
News Channels: Biological SCENE, Organic SCENE
Keywords: drug discovery, azide, click chemistry, cancer, drug conjugates, antibodies, bioorthogonal chemistry

A new small-molecule strategy could help target cancer drugs selectively to tumors with the help of click chemistry (Nat. Chem. Biol. 2017, DOI: 10.1038/nchembio.2297).

Many cancer drugs attack healthy tissue in addition to tumors, leading to harmful side effects. So scientists want to target therapeutics to cancer cells more selectively.

One such approach that has reached the clinic is antibody-drug conjugates. Antibodies recognize antigens, such as HER2 . . .

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