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Copyright © 2006 American Chemical Society
May 22, 2006 Cover
Volume 84, Issue 21
COVER: In nature, the toughest haiogenation jobs—halogenatin g unactivated organic molecules—fall to mononuclear iron enzymes like SyrB2, whose active site is shown here.
Volume 84, Issue 21
HALOGENASES
Enzymes responsible for installing halogen atoms in natural products with exquisite selectivity reveal their catalytic logic
COVER: In nature, the toughest haiogenation jobs—halogenatin g unactivated organic molecules—fall to mononuclear iron enzymes like SyrB2, whose active site is shown here.
Credit: Courtesy of Leah Blasiak
» Full Article
May 22, 2006 Issue
Volume 84, Issue 21
May 22, 2006 Issue, Vol. 84 | Iss. 21
Enzymes responsible for installing halogen atoms in natural products with exquisite selectivity reveal their catalytic logic
(pp. 12-18)
Features
Government & Policy
Small-molecule natural product is a potent antibiotic with a novel target (p.7)
Science & Technology
Attendance drops at biennial instrumentation trade show but still exceeds organizers' expectations (pp. 36-37)
News of the Week
Antibiotic Halts Lipid Synthesis
Small-molecule natural product is a potent antibiotic with a novel target
(p.7)Drugmaker Buys Key Biotech Firm
AstraZeneca's deal continues push of major pharma companies into biologics
(p.8)Supreme Court On Clean Air Act Case
High court will rule in suit over what constitutes an emissions increase
(p.8)Nanotube Speedway
Gas and water zoom through the carbon nanotube pores of a membrane
(p.9)Another Good Year
Profits are up in Japan, but rising costs present a challenge
(p.10)Analyzing Protein Interactions
Technique probes inhibitor-enzyme interactions comprehensively
(p.11)Departments
Business
Lower demand and rising costs continue to hamper results at 25 firms
(pp. 21-22)
First-quarter results signal that cost-cutting measures are helping the bottom line
(pp. 24-25)
Larger biotech firms are starting to feel the same portfolio challenges as big pharma companies
(pp. 25-26)
Mumbai's Arch Pharmalabs grows fast by buying distressed drug plants and hiring new managers
(p.27)Concentrates
(pp. 19-20)
(pp. 19-20)- Big companies invest in biodiesel
- Energy group set in France
- Diagnostic pact established
- BASF acquires biotech firm
- Engelhard, BASF vie for votes
- Venture targets specialty drugs
- Cognis buys producer of fish extract ...
- ... while Lonza acquires tree extract maker
- Dutch group forms biomedical partnership
- Chemical prices rise in April
- Dow's Doan dies at age 83
- Bayer has new TDI technology
- Roche allows generic Tamiflu
- Thais, Japanese float project
- Chemtura sells water additives
- Business Roundup
ACS News
R&D is not the place to cut costs, executive director tells Pittsburgh meeting attendees
(p.41)
Government & Policy
Members of a key Senate panel plan to include greater incentives for biofuels projects in farm policy overhaul
(pp. 29-31)
Generic drug producers are being paid to drop patent challenges, FTC says
(pp. 32-33)
National Academies report finds the agency trying to do too much with too little
(p.34)
Science & Technology
Enzymes responsible for installing halogen atoms in natural products with exquisite selectivity reveal their catalytic logic
(pp. 12-18)
Attendance drops at biennial instrumentation trade show but still exceeds organizers' expectations
(pp. 36-37)
Carbohydrate-coated carbon nanotubes mimic cell surfaces and interface with cells
(p.38)
New technique is analogous to magnetic resonance imaging, but without the radio pulses
(p.39)Career & Employment
Outside Boston's biotech hub, New England pitches specialized positions and a slower pace of life
(pp. 43-48)Newscripts
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