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Copyright © 2006 American Chemical Society
August 14, 2006 Cover
Volume 84, Issue 33
COVER: One of four identical subunitsof halohydrin dehalogenase withthe substrate ethyl (S)-4-chloro-3-hydroxybutyrate docked in the active site.
Volume 84, Issue 33
FINE CHEMICALS &PHARMACEUTICALS
Rapid screening and optimization of enzymatic activity, along with available, easy-to-use enzymes, are making biocatalysis a handy tool for chiral synthesis
COVER: One of four identical subunitsof halohydrin dehalogenase withthe substrate ethyl (S)-4-chloro-3-hydroxybutyrate docked in the active site.
Credit: Codexis
» Full Article
August 14, 2006 Issue
Volume 84, Issue 33
August 14, 2006 Issue, Vol. 84 | Iss. 33
Rapid screening and optimization of enzymatic activity, along with available, easy-to-use enzymes, are making biocatalysis a handy tool for chiral synthesis
(pp. 15-25)
Features
Science & Technology
Protective pathways may falter with age, sparking Alzheimer's neurodegeneration (p.9)
Science & Technology
Digital repositories have garnered mixed reviews—everything from enthusiasm to apathy (pp. 50-53)
Cover Story: Enzymes At Work
Competitors Want to Get a Piece of Lipitor
Biocatalysis offers a variety of enantioselective routes to key chiral intermediates for the drug
(pp. 26-27)Biocatalysis Helps Reach A Resolution
Enzymatic reactions combined with racemization can generate enantiopure materials in high yields
(pp. 29-31)News of the Week
Two-Path Mechanism
Protective pathways may falter with age, sparking Alzheimer's neurodegeneration
(p.9)Lost Lithium Located
Researchers restore confidence in standard picture of universe's birth by accounting for missing element
(p.10)Plot To Blow Up Airliners Foiled
Expert speculates on the liquid explosives that could have been used
(p.10)Enzymes For Designer Carbs
New screening approach is first to allow glycosyltransferase evolution
(p.12)DOE Continues Nuclear Push
Nuclear waste reprocessing gets aid, encouragement in new department plan
(p.13)Departments
Business
Entrepreneurial scientists are finding new careers in the shadow of the big chemical company
(pp. 34-38)
Finnish capital works to overcome image of frozen north and make new chemicals agency feel at home
(pp. 40-41)
Biocatalysis offers a variety of enantioselective routes to key chiral intermediates for the drug
(pp. 26-27)Concentrates
(pp. 32-33)
(pp. 32-33)- Dow will boost China epoxies with glycerin-based process
- Huntsman says sale is likely
- Tianjin blast kills seven
- GE launches green lines
- Rolando to head Degussa Corp.
- Dow forms a Russian venture
- Albemarle will sell Thann site
- Rohm and Haas sells paint arm
- DuPont signs R&D agreement
- China siloxanes plant advances
- Chemical jobs are still rising
- Biotech firms cut back staff
- Air Products licenses OLED materials
- Sumitomo slates polarizer plant
- BP shutters Alaska field
- Sigma buys Pharmorphix
- Business Roundup
Government & Policy
Intense scrutiny has provided methods of reduction but few answers about risk
(pp. 43-44)
Hearing discloses need for permanent, in-house science and technology resource
(pp. 46-48)
Science & Technology
Digital repositories have garnered mixed reviews—everything from enthusiasm to apathy
(pp. 50-53)
When small stretching forces are applied, DNA winds up more tightly rather than lengthening
(p.54)
German-U.S. collaborative effort embarks on project to sequence the Neanderthal genome
(p.55)
Archaeologists examine early labware in search of clues as to why they worked so well
(p.56)
Rapid screening and optimization of enzymatic activity, along with available, easy-to-use enzymes, are making biocatalysis a handy tool for chiral synthesis
(pp. 15-25)
Enzymatic reactions combined with racemization can generate enantiopure materials in high yields
(pp. 29-31)