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Copyright © 2007 American Chemical Society
February 26, 2007 Cover
Volume 85, Issue 9
COVER: Kosan's second-generation inhibitor of the protein Hsp90 is firmly anchored in the pocket created by a portion of Hsp90 and ATP
Volume 85, Issue 9
KILLING CANCER
Drugs targeting the protein Hsp90 push already unstable cancer cells to the brink
COVER: Kosan's second-generation inhibitor of the protein Hsp90 is firmly anchored in the pocket created by a portion of Hsp90 and ATP
Credit: Kosan Biosciences
» Full Article
February 26, 2007 Issue
Volume 85, Issue 9
February 26, 2007 Issue, Vol. 85 | Iss. 9
Drugs targeting the protein Hsp90 push already unstable cancer cells to the brink
(pp. 15-23)
Features
Government & Policy
Business groups maintain ambitious agenda but face tough battles on Capitol Hill (pp. 40-42)
Science & Technology
Historical research helps untangle the complex mythology of quinine synthesis (pp. 47-50)
Cover Story: Living On The Edge
Drug Designer
Infinity Scientist Lends Credibility To The Hsp90 Pursuit
(pp. 20-21)News of the Week
Halogen-Induced Cyclization
Long-sought enantioselective reaction leads to halogenated steroidal compounds
(p.9)Detecting Nuclear Materials
Two agencies unite to spur academic research in breakthrough technologies
(p.10)Molecular Close-Up
Images show motions of single, confined molecule
(p.11)Rail Strike Hits Canadian Firms
Chemical company executives call on Canadian government to act
(p.12)Columbus' Silver Mining Debunked
Chemistry rewrites history of precious-metal processing in New World
(p.13)Hazardous Waste
Facilities have been unequally sited in poor, minority communities
(p.13)Departments
Business
Phytochemicals get boost from advanced chemical analysis, synthesis
(pp. 27-29)
But year-to-year fourth-quarter performance masks slowing of growth as 2006 ended
(pp. 30-34)
Restructuring in the face of disappointing financial results obscures improving pipelines
(pp. 35-36)
Product successes in 2006 translate into growing sales and profits for biopharmaceutical firms
(pp. 37-38)Concentrates
(pp. 25-26)
(pp. 25-26)- Lyondell Invests In Propylene Oxide
- Scientist Pleads Guilty In Theft
- Toronto Research Continues Its Expansion
- Air Products Names Technology Officer
- Ineos to produce Phenol In China
- Eastman Will Sell Spanish Plant
- Nano-Terra Partners With Merck Kgaa
- DSM And BASF Make Venture Investments
- BP Assessing Gas Hydrate Potential
- BASF Sells Feed Premix Facilities
- Chemical Prices Slip In January
- Germany's Merck Shifts Head Again
- Aptuit Outlines Investment Plan
- Key Genentech Patent Rejected
- BUSINESS ROUNDUP
- All Concentrates
Government & Policy
Business groups maintain ambitious agenda but face tough battles on Capitol Hill
(pp. 40-42)
Lawmakers probe Bush directive, fearing decrease in their influence on regulations
(p.43)Books
A seasoned science writer analyzes how news is made
(pp. 52-53)
Science & Technology
Infinity Scientist Lends Credibility To The Hsp90 Pursuit
(pp. 20-21)
Drugs targeting the protein Hsp90 push already unstable cancer cells to the brink
(pp. 15-23)
Historical research helps untangle the complex mythology of quinine synthesis
(pp. 47-50)
Chemists have a vital role to play in achieving sustainability
(p.51)Newscripts
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