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Copyright © 2010 American Chemical Society
November 29, 2010 Cover
Volume 88, Issue 48
COVER: PLoS Comput.Biol
Volume 88, Issue 48
TIGHT SPACES
Crowded conditions such as those in cells can affect proteins’ structure, function, and activity
COVER: PLoS Comput.Biol
Credit: PLoS Comput.Biol
» Full Article
November 29, 2010 Issue
Volume 88, Issue 48
November 29, 2010 Issue, Vol. 88 | Iss. 48
Crowded conditions such as those in cells can affect proteins’ structure, function, and activity
(pp. 9-13)
Features
Business
Europe's Chemical Industry approaches first registration deadline and readies for more (pp. 15-17)
News of the Week
Yeast Ribosome Structure Solved
Crystallography: Details of translation machinery could help elucidate mechanism, regulation
(p.5)Low-Octane Climate Talks
Negotiations: Meeting in Mexico expected to produce only modest agreements
(p.6)Merck Advances Cholesterol Drugs
Clinical Trials: Positive new data for both Vytorin and anacetrapib
(p.6)Blast At Chinese Plant Kills Four
Coal Chemicals: Facility made polyvinyl chloride via the acetylene process
(p.7)Gulf Spill Burns Posed Little Risk To Health
Gulf Spill: Researchers estimate that surface slick burns produced very low levels of cancer-causing dioxins
(p.7)In Search Of Cysteines
Chemical Biology: New technique finds superreactive cysteines in proteins
(p.8)Roche Decision Reverbates
Pharmaceuticals: Drug firm’s exit from RNAi space hits Alnylam, Tekmira
(p.8)Departments
Business
Europe's Chemical Industry approaches first registration deadline and readies for more
(pp. 15-17)
NCI’s small-business program moves beyond its typical grants to help companies find partners
(pp. 18-20)
AMRI hopes to rebound following setbacks in its Pharma Services Expansion in 2010
(pp. 21-23)ACS News
Society President Joseph S. Francisco furthers international collaborations in 2010
(pp. 44-45)Awards
(p.46)
(p.46)- Shinya Yamanaka Wins Kyoto Prize
- Negishi And Suzuki Awarded Japan’s Order Of Culture
- Helen Free Award To William Deese
- George Whitesides Is Cotton Medalist
- Spencer Award Call For Nominations
- Terry Acree Wins AGFD Award
- Midwest Award To John Verkade
- Harrison Howe Award To Joseph DeSimone
- Nominations Sought For Skolnik Award
Government & Policy
FDA faces conflicting views on how to develop drug approval pathway
(pp. 25-27)
Republicans’ stance on global-warming science suggests a rough road ahead for researchers
(pp. 30-31)Books
Science & Technology
Crowded conditions such as those in cells can affect proteins’ structure, function, and activity
(pp. 9-13)
Chemists are taking to web tools to fulfill ‘broader impact’ requirement in NSF grants
(pp. 34-35)
RNA with less than perfect complementarity blocks expression of Huntington’s Disease gene sequence
(p.36)
Click-chemistry technique provides a nontoxic way to visualize biomolecules on cell surfaces in vivo
(p.37)