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Copyright © 2011 American Chemical Society
April 11, 2011 Cover
Volume 89, Issue 15
COVER: Genetech's GDC0941 bound in the active site of PI3Ky.
Volume 89, Issue 15
PI3K INHIBITORS
After a frenzy to develop better and more selective PI3K inhibitors, companies now must figure out how to use them in cancer patients
COVER: Genetech's GDC0941 bound in the active site of PI3Ky.
Credit: Genentech
» Full Article
April 11, 2011 Issue
Volume 89, Issue 15
April 11, 2011 Issue, Vol. 89 | Iss. 15
After a frenzy to develop better and more selective PI3K inhibitors, companies now must figure out how to use them in cancer patients
(pp. 15-19)
Features
Business
Strong Asian growth has reinvigorated the global petrochemical industry (pp. 22-23)
Government & Policy
U.S. seeks to secure deadly pathogens to prevent their use in bioterror attacks (pp. 30-32)
News of the Week
Solvay To Buy France’s Rhodia
Specialty Chemicals: $4.8 billion acquisition will create a global powerhouse
(p.9)Carbenes Map Protein Surface
Structural Biology: Highly reactive species nonselectively label amino acids
(p.10)Government Stalls
Congress: Partisan struggle to set the fiscal 2011 federal budget moves agencies toward closing
(p.10)Safer Carbonylations
Synthesis: New approach could ease small-scale carbon monoxide reactions
(p.11)Congress Splits On EPA CO2 Bill
Climate Change: Senate blocks, House backs legislation to ban EPA controls on greenhouse gases
(p.12)New Route To Graphene Devices
Nanoelectronics: Procedure draws on industry-compatible methods and materials
(p.12)Departments
Business
Strong Asian growth has reinvigorated the global petrochemical industry
(pp. 22-23)
Biofocus is pioneering the compound management business
(pp. 24-25)
Big pharma’s R&D revamping is hitting biotech company partners
(p.26)Concentrates
(pp. 20-21)
(pp. 20-21)- Pfizer Selling Capsugel To KKR
- Westlake To Expand Ethylene Capacity
- AkzoNobel To Boost Microsphere Facility
- Evans Analytical Buys Chemir Companies
- Lucite Resumes U.S. Methacrylic Acid
- DuPont Sues Over Trade Secret Theft
- JEOL Spins Off Its NMR Business
- Catalyst System Installed On Ferry
- Evolva Buys Stevia Research Partner
- Qiagen Gets Aussie Diagnostics Firm
- Bayer HealthCare Consolidates
- Millennium, Sunesis Link For Cancer Drugs
- Sino-American Firm Raises $100 Million
- Business Roundup
ACS News
Photos by Linda Wang
(pp. 42-43)
Government & Policy
U.S. seeks to secure deadly pathogens to prevent their use in bioterror attacks
(pp. 30-32)
Science & Technology
After a frenzy to develop better and more selective PI3K inhibitors, companies now must figure out how to use them in cancer patients
(pp. 15-19)
Paleochemistry: Resurrected enzyme reveals sophisticated mechanism of action
(p.34)
Imaging: Biobased label enables scientists to pinpoint proteins in cells, tissues
(p.34)
First enantioselective synthesis of nutlin-3 could lead to analogs for cancer studies
(p.41)Newscripts
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