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Copyright © 2014 American Chemical Society
January 20, 2014 Cover
Volume 92, Issue 3
COVER: An SAFC worker handles materials for the manufacture of antibody-drug conjugates.
Volume 92, Issue 3
Participants in a complex supply chain are gearing up to meet demand for an expected flood of targeted therapies
COVER: An SAFC worker handles materials for the manufacture of antibody-drug conjugates.
Credit: SAFC
» Full Article
January 20, 2014 Issue
Volume 92, Issue 3
January 20, 2014 Issue, Vol. 92 | Iss. 3
Participants in a complex supply chain are gearing up to meet demand for an expected flood of targeted therapies
(pp. 13-21)
Features
Business
Under a controversial patent regime, Indian companies supply pharmaceuticals to more and more patients globally (pp. 25-27)
Cover Story: Building Antibody-Drug Conjugates
Altered Antibodies Offer Improved Conjugates
Developers use mutagenesis to create specific sites for conjugating drugs
News of the Week
Toxicity Unknown
Pollution: Lack of hazard data hampers response to chemical spill in West Virginia
(p.7)KiOR Faces Plant Revamp
Alternative Energy: First-of-its-kind facility needs to go off-line to meet output goals
(p.8)Monsanto Seed Case Closed
Intellectual Property: Supreme Court refuses to revive challenge to company’s ability to sue for damages
(p.8)Chemists Present Innovative Methods For Reducing Alkenes And Coupling Them Directly
Organic Chemistry: First-row transition-metal-catalyzed processes build motifs in medicinally active molecules
(p.9)U.K. Approves Fracking
Shale Gas: Prime Minister supports natural-gas-extraction method, big oil company already invested
(p.9)Congress Sets 2014 Budget
Appropriations: Funding increases for R&D agencies under bipartisan deal
(p.10)Spotting Many Different Proteins On Single Cells
Analytical Biochemistry: DNA-based sensing of multiple proteins could aid personalized medicine
(p.10)RNA Drug Firms Attract Deals
Pharmaceuticals: Recent successes help boost emerging therapeutic field
(p.11)Taking On The Problem Of Reproducibility
Organizations call for standards to improve reproducibility in life sciences research
(p.11)Departments
Business
Under a controversial patent regime, Indian companies supply pharmaceuticals to more and more patients globally
(pp. 25-27)
Participants in a complex supply chain are gearing up to meet demand for an expected flood of targeted therapies
(pp. 13-21)
Inventing new medicines inside university walls requires complex funding and a highly collaborative research plan
(p.28)Concentrates
(pp. 23-24)
(pp. 23-24)- H.I.G. To Buy American Pacific
- AMEC Will Acquire Foster Wheeler
- Mitsubishi Halts Production After Blast
- Siluria, Braskem Collaborating
- IFF Snaps Up Israeli Ingredients Firm
- Symrise To Buy Probiotics Maker
- Vergnano To Lead DuPont Spin-off
- Illumina Boasts Genome Milestone
- Biogen And Sangamo Target Blood Diseases
- Two Biotech Firms To Shift Focus, Cut Jobs
- Regeneron Sets Eye Drug Pact
- Chinese Drug Firm In Graft Probe
- Business Roundup
ACS News
Dallas, March 16–20
(p.49)Awards(pp. 43-47)
(pp. 43-47)- 2014 ACS National Award Winners
- ACS Award In Separations Science & Technology
- Ernest Guenther Award In The Chemistry Of Natural Products
- Arthur W. Adamson Award For Distinguished Service In The Advancement Of Surface Chemistry
- Francis P. Garvan-John M. Olin Medal
- F. Albert Cotton Award In Synthetic Inorganic Chemistry
Government & Policy
Cities ban food and beverage containers made with the plastic foam
(pp. 31-32)Education
Skilled scientists help University of Delaware life sciences students make connections between chemistry and biology
(pp. 40-41)
Science & Technology
Researchers seek mechanism for cancer drug bexarotene’s alleged activity against Alzheimer’s
(pp. 38-39)
Two studies reveal intricacies of the roles acyl carrier proteins play in biosyntheses of fatty acids and lipid A
(pp. 36-37)Newscripts
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