Single Cell ICP-MS: A New Technique to Measure Nanoparticles and Metals in Individual Cells

September 20, 2017

7:00 a.m. PDT / 10:00 a.m. EDT / 15:00 BST / 16:00 CEST

Overview

The ability to rapidly measure the elemental concentration of individual cells, as well as the distribution in concentration throughout the cell population, has been a limiting factor in life science applications focusing on uptake rates, bioavailability, and bioaccumulation for drug delivery and toxicity assessment. Traditional methods for measuring uptake rates can be a time-consuming process with long instrument analysis and sample preparation time, often leading to qualitative or population-averaged results missing information about the heterogeneity and complexity of a cell population.

In this webinar, we will cover “Single Cell ICP-MS”, a new technique that offers a unique opportunity to quantitatively measure the metal content in individual cells, unveiling new capabilities to study intrinsic metals and the uptake of dissolved (ionic) and nanoparticulate metals into cells.

We will demonstrate the ability to quantify changes in exposure parameters such as precipitation of dissolved metal and the dynamic transformations of nanoparticles in complex media and match this to the uptake of metals in to individual fresh water algae cells. Showing for the first time if cell toxicity is due to uptake of the nanoparticulate or dissolved metals in the exposure media.

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