High Throughput ADME Solutions For Metabolic Profiling Using Mass Spectrometry
 
 
CEN Webinars: Stronger Bonds

High Throughput ADME Solutions
For Metabolic Profiling Using Mass Spectrometry

 

Thursday, August 30, 2012

USA 11:00 a.m. EDT / 10:00 a.m. CDT / 8:00 a.m. PDT / 15:00 GMT

 

Speakers


Suma Ramagiri, Ph.D.
Application Scientist
Product Application and Development Lab
AB SCIEX



Veronica Zelesky
Scientist,
HTS ADME
Pfizer


Moderator


Celia Arnaud
Senior Editor
C&EN
 


 

Overview:


Identification of metabolic soft spots in early stage ADME screening should accelerate drug discovery via a reduction in synthetic cycles and/or abandonment of problematic templates earlier in the discovery process. Currently high-throughput metabolic stability studies in microsomes are used to guide synthesis when there is need to modulate clearance. Providing structural information alongside clearance data will allow design chemists to make more streamlined synthesis decisions. HRMS technology coupled with software automation tools that leverage real time multiple defect filtering (MMDF) technology have significantly increased the throughput speed of soft spot identification studies. Here we describe two software packages, MetabolitePilot® (AB SCIEX) and MassMetasite® (Molecular Discovery), that were investigated in an effort to develop a high-content metabolic stability screening model.

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