Emerging Analytical Solutions for Early ADME
Tuesday, July 24, 2012
USA 11:00 a.m. EDT / 10:00 a.m. CDT / 8:00 a.m. PDT / 15:00 GMT
Who should attend?
• Researchers who conduct in vitro ADME assays such as metabolic stability, permeability, PAMPA, CYP enzyme assays
• Researchers engaged in drug metabolite profiling, identifica- tion, quantification and structural characterization
• Lab managers and scientists focused on ADME research in Biotech, Pharmaceutical companies and CRO's
• Project leaders, medicinal chemists and biologists interested in obtaining critical ADME data to drive their drug discovery programs forward
• Academicians and students interested in new ADME en- abling analytical technologies
Vaughn Miller, Ph.D.
Yuqin Dai, Ph.D.
Senior Application Scientist
Dave Rusell, Ph.D.
Ann Thayer, Ph.D.
Changes in the regulatory requirements for drug candidates as well as the need for Pharmaceutical companies to minimize late stage attrition has resulted in greater emphasis on selecting candidates with the best ADME properties early in discovery. In this webinar you will learn about analytical technologies that can provide unique, innovative, and robust data to address the growing needs of your ADME laboratory.
Webinar Participants Will Learn:
• How to perform a variety of in vitro ADME assays with unprecedented throughputs of >350 samples per hour and generate a seven point IC50 curve in under 45 seconds, without compromising data quality, using existing assay methods and workflows.
• How to maximize information from early ADME mass spectrometry data by obtaining qualitative as well as quantitative information simultaneously and without time-consuming method development and re-running samples, all at 1μM substrate concentrations.
• How to completely characterize nanomoles of isolated metabolites, perform mixture analysis on an analyte of interest in a complex matrix, and quantitate low nanomoles of analytes with absolute confidence and without the need for reference standards by utilizing value added NMR data
Come and join us for an information-packed Webinar and learn new and exciting ways to perform crucially important ADME analyses!