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Automated Zeta Potential to Characterize
the Charge for Proteins and Particles
Tuesday, May 22, 2012
USA 11:00 a.m. EDT / 10:00 a.m. CDT / 8:00 a.m. PDT / 15:00 GMT
Who should attend?
• Scientists interested in characterizing macromolecular or particle charge in solution.
• Researchers who wish to automate mobility measurements and increase the throughput of their research and experiments.
• Researchers who wish to measure electrophoretic mobility of samples with high conductivities.
• Formulation scientists.
• Researchers who want to learn about a state-of-the-art analytical technique for efficiently characterizing proteins, particles and polymers in solution.
Speaker
Dr. Vincent Hsieh, Ph.D.,
Senior R&D Scientist,
Wyatt Technology
Corporation
Moderator
Elizabeth K. Wilson
Senior Editor
C&EN
This webinar will present a few of the latest developments associated with electrophoretic mobility measurement techniques. The emphasis will be placed on three recent milestones in this measurement technique including:
• Breakthroughs in detection sensitivity.
• Zeta-potential measurements that can be automated using a common autosampler.
• The ability to measure samples in highly saline solutions where electrolysis previously rendered the measurements impossible to make.
During the webinar, we will show how zeta-potential measurements can be automated for unattended acquisition of mobility and size data. The eternal issue of the electrolysis problem faced by researchers while characterizing samples in high-salt solutions has been resolved and will be discussed. Now samples with high conductivities (near or above physiological saline) can be measured.
What Participants Will Learn:
• Principles of mobility measurements: what is phase-analysis light scattering (PALS), and how it has evolved into multiple angle PALS.
• How biomolecules can be measured without denaturing them.
• How zeta potential instruments can be combined with an HPLC pump and autosampler to enable high-throughput, unattended measurement of electrophoretic mobility and hydrodynamic radius.
• How zeta potential instruments can be combined with an HPLC pump and autosampler to enable high-throughput, unattended measurement of electrophoretic mobility and hydrodynamic radius.
