Volume 84 Issue 39 | pp. 97-98
Issue Date: September 25, 2006

Proline Is Found To Prevent Protein Aggregation

Department: Science & Technology, ACS News

A small molecule that normally helps a cell survive dehydration can also prevent the formation of protein aggregates that lead to Huntington's disease.

When a cell is exposed to salty conditions, or high osmolarity, water exits the cell, thereby increasing the concentration of proteins that are already in an extremely crowded environment. This stressful situation can lead to protein misfolding. To cope, the cell turns on a cell membrane pump that transports small molecules called . . .

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