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Web Date: March 8, 2006

Drug Eases Alzheimer's In Mice

Treatment reduces pathological hallmarks of disease
Department: Science & Technology

The experimental drug AF267B improves memory and reduces brain pathology in a transgenic mouse model of Alzheimer???s disease, according to University of California, Irvine, neurobiologist Frank M. LaFerla and colleagues (Neuron 2006, 49, 671).

As the disease develops in humans and in the team???s transgenic mice, amyloid plaques and neurofibrillary tangles of tau protein accumulate in the brain; levels of the neurotransmitter acetylcholine also decline. AF267B mimics the missing neurotransmitter. When the drug binds . . .

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