Volume 85 Issue 30 | p. 29 | Concentrates
Issue Date: July 23, 2007

Small Molecules Disrupt RNA Splicing

Department: Science & Technology
News Channels: JACS In C&EN

The identification of the first small molecules capable of disrupting the work of the spliceosome promises new insight into how this crucial biological machine helps convert DNA into proteins (Nat. Chem. Biol., DOI: 10.1038/nchembio.2007.16 and 10.1038/nchembio.2007.18). Before raw RNA transcripts of protein-coding genes can be converted into protein, the spliceosome must remove any unwanted and intervening RNA segments. Failure to splice out such intervening sequences, commonly called introns, before translation gives rise to flawed and . . .

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