Volume 85 Issue 52 | p. 35 | Concentrates
Issue Date: December 24, 2007

H-Bonds Control Amyloids

Department: Science & Technology

Amyloid protein fibrils are best known as bad actors in Alzheimer's and related diseases. But they can also serve functional roles, as bacterial coatings, for example, suggesting that amyloids might become useful as designed synthetic materials. Although the flexibility or rigidity of the fibrils varies over a range of four orders of magnitude, the factors determining such properties are not well-known. A major factor controlling this flexibility or rigidity turns out to be the fibrils' . . .

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