Issue Date: June 16, 2008
New Route To α-Alkylated Ketones
A new method for asymmetrically α-alkylating ketones—adding alkyl substituents to carbons adjacent to ketone groups to give chiral products—is simpler and more amenable to scale-up than current approaches, according to Duke University's Daniel Lim and Don M. Coltart, the researchers who devised the procedure (Angew. Chem. Int. Ed., DOI: 10.1002/anie.200800848). In the reaction, a ketone is combined with a chiral N-amino cyclic carbamate (ACC, red) to generate a hydrazone, which is then . . .
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