Volume 86 Issue 27 | p. 24 | Concentrates
Issue Date: July 7, 2008

Organic Fluorophore Switches On Demand

Department: Science & Technology

High-resolution, single-molecule imaging methods such as PALM and STORM require fluorophores that can be switched on and off on demand. Those methods often rely on fluorescent proteins that photobleach quickly and don't produce as many photons as small-molecule organic fluorophores. A team of chemists led by Stanford University's W. E. Moerner and Kent State University's Robert J. Twieg, report a new photoactivatable small organic fluorophore that's suitable for live-cell imaging (J. Am. Chem. Soc., DOI: . . .

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