Volume 86 Issue 46 | p. 55 | Concentrates
Issue Date: November 17, 2008

Acrobatic HIV Enzyme Caught In Action

New mechanistic finding on reverse transcriptase???s sliding and flipping catalytic motions could help advance AIDS drug design
Department: Science & Technology

New mechanistic findings on a key HIV enzyme could help advance AIDS drug design, according to a report in Science (2008, 322, 1092). Reverse transcriptase (RT) is an essential enzyme in the life cycle of HIV and a target of AIDS drugs such as azidothymidine (AZT). But aspects of RT's mechanism have remained a mystery. Although the mechanism has been studied by crystallography and other techniques, the acrobatic moves RT undergoes while converting HIV's RNA . . .

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