Volume 86 Issue 49 | p. 30 | Concentrates
Issue Date: December 8, 2008

Fatty Food Reactions Suppress Appetite

Lipids and a protein secreted after a high-fat meal curb appetite—at least in rodents
Department: Science & Technology

Appetite-suppressing compounds produced by rodents after eating a high-fat meal could lead to methods to prevent or treat obesity if they function in a similar fashion in humans. Yale University's Gerald I. Shulman, Matthew P. Gillum, and colleagues determined that after eating a greasy meal, mice and rats produce N-acylphosphatidylethanolamines (NAPEs) in the small intestine. These lipids then travel in the blood to the brain, where they suppress appetite. The researchers showed that mice . . .

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