Volume 86 Issue 8 | p. 38 | Concentrates
Issue Date: February 25, 2008

Acetyl On Demand

Department: Science & Technology

Covalent addition of acetyl groups to lysine's side-chain nitrogen is a reversible process that regulates essential events such as DNA replication and repair. Deciphering the roles of acetylation in biology has been challenging because it is difficult to make pure protein that is acetylated at a single site. Now, Jason W. Chin and coworkers at the Medical Research Council Laboratory of Molecular Biology, in Cambridge, England, have genetically encoded side-chain-acetylated lysine (Nε-acetyllysine, shown) into . . .

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