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Web Date: October 15, 2008

Spotting Nascent Protein Crystals

Optical technique reduces background noise and could cut screening times and costs
Department: Science & Technology
News Channels: JACS In C&EN

A microscopy technique that harnesses a special optical effect could detect smaller protein crystals than can any other optical method. The technique may reduce the time and expense required to screen crystallization conditions, a major bottleneck in protein structure determination by X-ray crystallography.

Traditional high-throughput crystal screens can find only protein crystals that are at least micrometer-sized. Some screens also have a significant background signal due to fluorophores used in detection. Garth J. . . .

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