Volume 87 Issue 18 | pp. 46-49
Issue Date: May 4, 2009

Divining The Spliceosome

The missing link between humanity's small genome and huge proteome reveals some secrets
Department: Science & Technology

WHEN WE HUMANS got a first glimpse of our genome, we had good reason to question our biological complexity. Many scientists predicted we would possess some 100,000-plus genes, but sequencers finally capped the human genome at 20,000–25,000 genes. The size of the human genome is cause for a little existential malaise, considering that the lowly worm Caenorhabditis elegans also has about 20,000 genes.

To further complicate matters, humanity's paltry gene count doesn't add up to . . .

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