Volume 87 Issue 2 | p. 37 | Concentrates
Issue Date: January 12, 2009

Ribosome Has A Third Fidelity Trick Up Its Sleeve

Researchers discover a third step that is key to ensuring the accuracy of ribosomal protein biosynthesis
Department: Science & Technology

The high accuracy of ribosomal protein synthesis was believed to rely on the fidelity of two key biosynthetic steps, but a research team has found that a previously unknown step is a third important contributor to the fidelity of the process (Nature 2009, 457, 161). The two known steps on which mistake-free protein synthesis depends are the enzymatic addition of correct amino acids to each of the amino acid-specific transfer RNAs and the ribosome's selection . . .

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