Volume 87 Issue 27 | p. 25 | Concentrates
Issue Date: July 6, 2009

Nanoparticle Double Whammy Kills Tumors

Inactive Salmonella cells loaded with siRNA and anticancer agents show promise as delivery vehicles for a combination drug therapy
Department: Science & Technology
Keywords: siRNA, gene therapy, nanoparticles, targeted delivery

Nanoparticles loaded with small interfering RNAs (siRNAs) can render aggressive, drug-resistant tumors more susceptible to treatment by anticancer agents, prolonging the lives of cancer-stricken mice indefinitely, according to a research team led by Jennifer A. MacDiarmid and Himanshu Brahmbhatt of EnGeneIC, an Australian biotech company (Nat. Biotechnol., DOI: 10.1038/nbt.1547). Key to the strategy is packaging siRNAs in minicells, which are 400-nm, inactive, empty bacterial cells that can function as targeted delivery . . .

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