Volume 87 Issue 30 | p. 46 | Concentrates
Issue Date: July 27, 2009

Downsizing Drugs

Cocrystallization helps compress an active ingredient into a tablet
Department: Science & Technology
News Channels: JACS In C&EN
Keywords: Crystallization, Acetaminophen, Cocrystals, Pill Size

Bulky acetaminophen pills can be a headache to swallow. That's because crystals of the analgesic don't easily compress into a stable tablet without the addition of binding agents that increase the pill's girth. A new proof-of-principle study suggests one possible weight-loss program for the hefty tablets is to crystallize the active ingredient with companion molecules, thus producing a more compressible crystal.

In particular, William Jones, a chemist at Cambridge University, and . . .

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