Volume 87 Issue 40 | p. 36 | Concentrates
Issue Date: October 5, 2009

Microgel Enzyme Inhibitor

A molecularly imprinted polymer selectively inhibits trypsin better that one of the enzyme's known small-molecule inhibitors
Department: Science & Technology
News Channels: JACS In C&EN
Keywords: microgel, polymer, enzyme inhibition

A polymer formed around an enzyme—a construction known as a molecularly imprinted polymer (MIP)—can selectively inhibit the enzyme much better than a related small-molecule inhibitor, indicating that MIPs could be useful for drug development (J. Am. Chem. Soc., DOI: 10.1021/ja901600e). Scientists have had aspirations of using MIPs for analytical chemistry and biochemical applications, but the biological activity of the molded macromolecules has remained unprobed. A group led . . .

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