Volume 87 Issue 42 | p. 36 | Concentrates
Issue Date: October 19, 2009

Trimming Sugars Yields Better Flu Antibodies

Truncating sugar chains on coat protein may lead to a new vaccine for the virus
Department: Science & Technology
Keywords: influenza, hemagglutinin, glycosylation, glycan, vaccine

Truncating the sugar chains attached to an influenza protein leads to antibodies that can better bind to and neutralize the virus, reports a group led by Che Ma and Chi-Huey Wong at Academia Sinica, in Taiwan (Proc. Nat. Acad. Sci. USA, DOI: 10.1073/pnas.0909696106). The team investigated the glycosylation of influenza hemagglutinin (HA), a glycoprotein on the viral coat that enables the virus to enter respiratory-tract cells by binding to glycan receptors. The team . . .

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