Volume 87 Issue 45 | p. 41 | Concentrates
Issue Date: November 9, 2009

Solvent-Free Peptide Synthesis

French chemists employ a ball-mill grinder to string together amino acids in the first reported solvent-free method for making a peptide bond
Department: Science & Technology
Keywords: peptide bond

Stringing amino acids into a peptide typically takes a large amount of solvent. Chemists in France led by Frédéric Lamaty of the Institut des Biomolécules Max Mousseron, in Montpellier, have now developed the first solvent-free method for making a peptide bond by employing a ball-mill grinder commonly used to process chemicals in paints and pyrotechnics (Angew. Chem. Int. Ed., DOI: 10.1002/anie.200903510). The device consists of a hollow cylinder containing multiple steel . . .

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