Volume 87 Issue 46 | pp. 41-43
Issue Date: November 16, 2009

Prelude To A Kiss Of Death

Targeting early steps in protein disposal could lead to drugs for cancer and more
Department: Science & Technology
Keywords: Drug Discovery, Cancer, Ubiquitin, Proteasome

Five years ago, the cell's trash disposal system was the toast of science when the three researchers who discovered it shared the 2004 Nobel Prize in Chemistry. In 2003, the first drug targeting it was approved by the Food & Drug Administration to treat patients with multiple myeloma, a type of white-blood-cell cancer. The achievements were a boost for researchers studying the system, called the ubiquitin-proteasome pathway. But the next stage of research hasn't exactly . . .

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