Volume 88 Issue 1 | p. 26 | Concentrates
Issue Date: January 4, 2010

Colloidal Lenses Turn Up The Heat

Spherical colloidal particles in combination with temperature-sensitive objectives function as lenses for single-molecule imaging
Department: Science & Technology
News Channels: Analytical SCENE
Keywords: colloids, single-molecule imaging

Some biological systems are too hot for single-molecule-imaging studies: At temperatures higher than 50 °C, heat conduction from the sample to the immersion objective through a refractive-index-matching oil can cause the high-numerical-aperture lens to fail. Stephen R. Quake, Jerrod J. Schwartz, and Stavros Stavrakis of Stanford University now show that spherical colloidal particles can be used in combination with low-numerical-aperture air objectives as lenses for high-temperature single-molecule imaging (Nat. Nanotechnol., DOI: 10.1038/nnano.2009.452). Quake . . .

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