Volume 88 Issue 10 | pp. 38-39
Issue Date: March 8, 2010

Predicting Amyloid Formation

Computer algorithms find fibril-forming sequences in nearly all proteins
Department: Science & Technology
Keywords: amyloid, fibril, computational biology

Clumps of protein fibrils known as amyloids play a role in a number of diseases, most famously Alzheimer’s and Parkinson’s. These fibrils are rich in β-sheets, a type of flat secondary protein structure. Being able to predict which proteins are likely to form amyloids could provide a way to discover drugs that prevent potential damage.

Scientists have now moved closer to being able to predict what portions of proteins have the ability to form amyloids . . .

To view the rest of this content, please log in with your ACS ID.

Chemical & Engineering News
ISSN 0009-2347
Copyright © American Chemical Society