Volume 88 Issue 12 | p. 43 | Concentrates
Issue Date: March 22, 2010

Shaken And Stirred Self-Replication

Different-sized molecules can come from one combinatorial library, depending on the agitation method
Department: Science & Technology
Keywords: shaking, self-assembly, dynamic combinatorial chemistry, agitation

Different self-replicating molecules can be synthesized from the same dynamic combinatorial library, depending on whether the starting solution is shaken, stirred, or unagitated, researchers find (Science 2010, 327, 1502). Sijbren Otto of the University of Groningen, in the Netherlands, and coworkers oxidized a peptide-derivatized aromatic dithiol, inducing it to oligomerize via disulfide formation into macrocycles of various size, which were in equilibrium with one another. Some of the macrocycles stack noncovalently, forming fibers that . . .

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