Volume 88 Issue 15 | p. 28 | Concentrates
Issue Date: April 12, 2010

Slipping In An Acetyl For Enzyme Control

Controlled acetylation inhibits isomerase activity of cyclophilin A, which could lead to new antiviral treatments
Department: Science & Technology
Keywords: acetylation, HIV, cyclophilin A

Acetylation of proteins helps biological cells control a number of processes, including glycolysis and DNA repair. But the inability to install an acetyl group on a specific lysine residue in the lab has stymied biochemical studies of this posttranslational modification. A team led by Leo C. James and Jason W. Chin of the Medical Research Council Laboratory of Molecular Biology, in Cambridge, England, has used a method previously created by Chin’s . . .

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