Volume 88 Issue 19 | p. 36 | Concentrates
Issue Date: May 6, 2010

How Aging Damages Memory

Neuroscience: Exploring the mechanism behind memory impairment points to a possible solution
Department: Science & Technology
Keywords: neuroscience, memory, aging, histones, acetylation

The results of a recent study into the origin of age-related memory impairment offer hope that this type of cognitive decline can be reversed (Science 2010, 328, 753).

Prior research suggested that gene expression employed by the brain for memory consolidation is partly controlled by acetylation of histones, the proteins around which DNA is wrapped. Other research indicated that gene expression in the brain is also affected by aging. In the new study, André . . .

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