Volume 88 Issue 19 | p. 36 | Concentrates
Issue Date: May 10, 2010

Manipulating Stem Cells Through Their Metabolites

Stem-cell differentiation can be regulated by controlling unsaturated metabolites
Department: Science & Technology | Collection: Stem Cells
Keywords: stem cell, metabolite, unsaturated molecules, reduction

Stem cell differentiation—the process of turning a blank stem cell into a specific type of cell—can be regulated by controlling the reduction of stem cell metabolites, chemists at Scripps Research Institute have found (Nat. Chem. Biol., DOI: 10.1038/nchembio.364). Stem cells contain a pool of unsaturated molecules that decrease as stem cells mature. Oscar Yanes, Sheng Ding, and Gary Siuzdak discovered that they can inhibit differentiation by blocking certain enzymes that reduce . . .

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