Volume 88 Issue 22 | p. 51 | Concentrates
Issue Date: May 31, 2010

Single-Molecule Assay Detects Cancer

Quanterix has developed an assay that is ultrasensitive for detecting a cancer biomarker
Department: Science & Technology
News Channels: Analytical SCENE
Keywords: Prostate-specific antigen, biomarker, single-molecule array, cancer, Quanterix

A Massachusetts company has developed an assay that is 1,700 times more sensitive for detecting a cancer biomarker than existing tests (Nat. Biotechnol., DOI: 10.1038/nbt.1641). The technology, which Cambridge-based Quanterix calls SiMoA (single-molecule array), uses femtoliter-sized chambers to individually isolate antibody-coated microbeads that trap single biomarker molecules. Labeling the biomarker with an enzyme permits its detection by fluo­res­cence microscopy. Quanterix researchers led by David C. Duffy in collaboration with Tufts University’s . . .

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