Volume 88 Issue 23 | pp. 39-40
Issue Date: June 7, 2010

Enzyme’s Metal Cluster Is Nailed

Definitive solution of the structure of an enzyme in isoprenoid biosynthesis could lead to new antibiotics
Department: Science & Technology
News Channels: JACS In C&EN
Keywords: IspH, non-mevalonate pathway

A long-standing disagreement over the structure of a key metalloenzyme is over, thanks to efforts by several groups. The enzyme, called IspH, is found in pathogenic microorganisms but not in humans, making it a promising drug target, because medications aimed at it would kill the microorganisms without adversely affecting the people infected by them.

IspH has been an active focus of research by several groups for almost a decade. But difficulties in studying its iron-sulfur . . .

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